Behavioral analysis of Ste20 kinase SPAK knockout mice
نویسندگان
چکیده
منابع مشابه
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.
Polymorphisms in the gene encoding sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) associate with hypertension susceptibility in humans. SPAK interacts with WNK kinases to regulate the Na(+)-K(+)-2Cl(-) and Na(+)-Cl(-) co-transporters [collectively, N(K)CC]. Mutations in WNK1/4 and N(K)CC can cause changes in BP and dyskalemia in humans, but the physiologic role of SPAK in vivo is un...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2010
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2009.12.005